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DIYgenomics Health Risk Web Application

Side-by-side comparison of consumer genomic services (deCODEme, Navigenics, and 23andme) by locus, gene, and variant for 20 conditions (diabetes, cancers, heart disease, etc.). If a company reviews the variant, the underlying research reference is posted in the table below. 'Sample data' displays the normal allele in green, the risk allele in red (risk allele identification methodology). 'Rank' is a composite score assigned to the variant by DIYgenomics per journal ranking, number of cases and controls, p-value, and odds ratio (rank assessment methodology).

NOTE: The information on this page is intended for research and educational purposes only, and is not for diagnostic use.

Variants reviewed for Obesity

//FOR FIRST APP - HEALTH
Locus Gene VariantdeCO-ooooo-DEme Navigenics 23andMe Nebula NIH SNP (Ref/Alt) Sample data Rank
1p31.1 NEGR1 rs2568958 A/G GG 5
1q25.2 SEC16B rs10913469 C/T CT 5
2p25.3 TMEM18 rs7561317 A/G GG 5
3q27.2 ETV5 rs7647305 C/T CC 5
5q15 PCSK1_2 rs6235 1 C/G CG 4
6p21.33 AIF1/NCR3 rs2844479 G/T AA 5
11p14.1 BDNF rs6265 A/G CC 5
12q13.13 FAIM2 rs7138803 A/G GG 5
16p11.2 SH2B1 rs4788102 A/G AG 5
16q12.2 FTO rs3751812 2,4,5,8,9,11 G/T GT 3
16q12.2 FTO rs9939609 4 A/T AT 5
18q21.32 MC4R rs10871777 3,6,7,12 A/G AA 3
18q21.32 MC4R rs12970134 A/G GG 5
19q13.11 KCTD15 rs29941 C/T AG 5

Research references cited by consumer genomic companies:

  1. Benzinou M et al; Common nonsynonymous variants in PCSK1 confer risk of obesity; Nat Genet; 2008 Aug;40(8):943-5.
  2. Dina C et al; Variation in FTO contributes to childhood obesity and severe adult obesity; Nat Genet; 2007 Jun;39(6):724-6.
  3. Farooqi IS et al; Dominant and recessive inheritance of morbid obesity associated with melanocortin 4 receptor deficiency; J. Clin. Invest.; 2000; 106(2):271-9.
  4. Frayling TM et al; A common variant in the FTO gene is associated with body mass index and predisposes to childhood and adult obesity; Science; 2007 May 11;316(5826):889-94.
  5. Gerken T et al; The obesity-associated FTO gene encodes a 2-oxoglutarate-dependent nucleic acid demethylase; Science; 2007 Nov 30;318(5855):1469-72.
  6. Loos RJ et al; Common variants near MC4R are associated with fat mass weight and risk of obesity; Nat. Genet.; 2008; 40(6):768-75.
  7. Meyre D et al; Genome-wide association study for early-onset and morbid adult obesity identifies three new risk loci in European populations; Nat. Genet.; 2009; 41(2):157-9.
  8. Scott LJ et al; A genome-wide association study of type 2 diabetes in Finns detects multiple susceptibility variants; Science; 2007 Jun 1;316(5829):1341-5.
  9. Scuteri A et al; Genome-wide association scan shows genetic variants in the FTO gene are associated with obesity-related traits; PLoS Genet; 2007 Jul;3(7):e115.
  10. Thorleifsson G et al; Genome-wide association yields new sequence variants at seven loci that associate with measures of obesity; Nat Genet; 2009 Jan;41(1):18-24.
  11. Wahlen K et al; The common rs9939609 gene variant of theft mass- and obesity-associated gene FTO is related to fat cell lipolysis; J Lipid Res; 2008 Mar;49(3):607-11.
  12. Willer CJ et al; Six new loci associated with body mass index highlight a neuronal influence on body weight regulation; Nat. Genet.; 2009; 41(1):25-34.

Glossary:
Locus (plural loci): the specific location of a gene or DNA sequence on a chromosome, (e.g.; 8p21.1 is the p21.1 region on Chromosome 8).
Gene: a series of variants at a locus that code for proteins or RNA chains.
Variant: the specific location with two alleles (e.g.; 'CG') or genotype values. Companies may review different variants in the same gene and locus.

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