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DIYgenomics Health Risk Web Application

Side-by-side comparison of consumer genomic services (deCODEme, Navigenics, and 23andme) by locus, gene, and variant for 20 conditions (diabetes, cancers, heart disease, etc.). If a company reviews the variant, the underlying research reference is posted in the table below. 'Sample data' displays the normal allele in green, the risk allele in red (risk allele identification methodology). 'Rank' is a composite score assigned to the variant by DIYgenomics per journal ranking, number of cases and controls, p-value, and odds ratio (rank assessment methodology).

NOTE: The information on this page is intended for research and educational purposes only, and is not for diagnostic use.

Variants reviewed for Aging

Locus Gene Variant deCODEme Navigenics 23andMe dbSNP (Nrml/Rsk) Sample data Rank
1._8q24.22 ZNF406 rs1036819 1 A/C AC 5
2._13q13.3 LHFP rs9576827 1 A/G AA 5
3._19q13.32 APOE/TOMM40 rs2075650 1 A/G AA 5
4._4q21.21 rs1455311 1 C/T AA 5
5._12q13.11 rs10880908 1 C/T CT 5
6._8q12.1 rs1436013 1 G/T TT 5
7._5q31.1 LOC441108 rs1003533 1 C/T CC 5
8._17p13.1 STX8 rs10521157 1 A/G GG 5
9._1q44 rs10924270 1 A/G AG 5
10._10q24.2 CRTAC1 rs508001 1 A/C AA 5
11._2q12.3 SULT1C3 rs2219078 1 A/G GG 5
12._11q12.2 MGC35295 rs7930940 1 A/G AG 5
13._18q22.1 rs8093550 1 C/T TT 5
14._16p13.13 LOC400499 rs4129933 1 G/T AC 5
15._20p13 VISA rs4815617 1 C/T CC 5
16._14q21.1 TTC6 rs12896790 1 G/T TT 5
17._2q37.1 DKFZp762E1312 rs579327 1 A/G CC 5
18._10p14 rs2462692 1 A/C GG 5
19._6q14.3 rs806606 1 C/T CC 5
20._1q44 rs4916176 1 A/C AA 5
21._8q21.11 rs10106137 1 A/C AC 5
22._8q23.2 rs3133926 1 A/G AA 5
23._9q22.31 SUSD3 rs9696357 1 C/T CC 5
24._8q21.13 ZNF704 rs4308687 1 A/G AG 5
25._15q13.1 rs4780054 1 C/T CT 5
26._5q12.3 FLJ46010 rs10069397 1 C/T CT 5
27._8p23.1 FDFT1 rs11250168 1 G/T GG 5
28._15q14 FAM98B rs11073328 1 C/T CC 5
29._13q31.3 GPC5 rs7988257 1 A/C AC 5
30._4q22.1 rs6532059 1 C/T CT 5
31._3p24.3 FGD5 rs294636 1 A/C TT 5
32._17q21.32 IGF2BP1 rs2411759 1 C/T CC 5
33._2p25.2 rs1377638 1 C/T CC 5
34._12q24.22 KSR2 rs7965602 1 C/T CT 5
35._4q32.2 rs6856902 1 A/G GG 5
36._3p22.3 rs6770257 1 C/T TT 5
37._9p21.2 TEK rs1322048 1 T/C CC 5
38._8q21.12 IL7 rs2717536 1 C/T GG 5
39._17q22 MSI2 rs792376 1 C/T GG 5
40._3p13 EIF4E3 rs12629971 1 C/T CC 5
41._10q21.3 CTNNA3 rs16922827 1 G/T TT 5
42._18p11.21 SPIRE1 rs11663391 1 A/C AA 5
43._20p13 rs1810636 1 T/G CC 5
44._5q32 STK32A rs4705038 1 A/C CC 5
45._11q24.2 FLJ21103 rs512577 1 G/A CT 5
46._2q31.1 GORASP2 rs4668356 1 C/T TT 5
47._3q24 rs1456669 1 A/C AC 5
48._16p12.1 rs7201268 1 A/G GG 5
49._13q31.1 rs4128764 1 A/G AA 5
50._10q25.1 SORCS1 rs7907713 1 A/G AA 5
51._16q12.2 rs7199196 1 C/T CT 5
52._8q24.3 ZC3H3 rs4874147 1 C/T CC 5
53._5q35.2 ATP6V0E rs12654739 1 C/T TT 5
54._7p22.2 rs936909 1 C/T GG 5
55._2q37.2 SH3BP4 rs2042831 1 A/G GG 5
56._18q23 rs590218 1 A/G AA 5
57._1p36.32 MORN1 rs903901 1 A/G GG 5
58._3p24.3 rs6770065 1 A/G AA 5
59._22q11.23 LOC388882 rs6519442 1 T/G TT 5
60._18p11.31 rs7504165 1 C/T CC 5
61._4p15.33 rs6811874 1 A/G AA 5
62._6p21.33 POU5F1 rs2073724 1 C/T CC 5
63._22q12.3 rs1894605 1 G/T GT 5
64._2q36.2 rs2042086 1 A/G TT 5
65._16q23.1 LDHD rs1579333 1 A/G CC 5
66._9p21.2 rs997675 1 T/C GG 5
67._17q21.32 GIP rs9899404 1 C/T TT 5
68._3q26.1 rs12489747 1 A/G GG 5
69._3p13 GPR27 rs6801173 1 C/T CC 5
70._4q31.3 rs6817112 1 C/T CT 5
71._5q14.1 RASGRF2 rs10514211 1 A/G AA 5
72._12q22 rs337656 1 A/G TT 5
73._18q22.3 rs1550650 1 G/T GG 5
74._7q31.33 GRM8 rs2188186 1 A/C CC 5
75._13q21.2 rs1340573 1 A/G AA 5
76._10q21.3 rs2247549 1 A/G GG 5
77._20q13.31 rs6128112 1 C/T CC 5
78._11p15.1 NAV2 rs1442709 1 T/C AA 5
79._2q35 rs9989823 1 C/T TT 5
80._8q24.22 rs2958832 1 A/G AA 5
81._9p21.3 rs4977756 1 A/G AG 5
82._2p25.3 rs2043544 1 G/A CT 5
83._2q37.3 rs7581699 1 G/T TT 5
84._5q15 ELL2 rs147295 1 C/T CT 5
85._18p11.21 C18orf1 rs12606866 1 A/C AC 5
86._5p15.31 rs275490 1 C/T CT 5
87._10q23.33 rs11812285 1 A/C AC 5
88._4p14 rs4073968 1 G/A CT 5
89._19q13.31 CEACAM16 rs4802234 1 G/T TT 5
90._11q24.2 DCPS rs651922 1 C/T AG 5
91._18q21.33 TNFRSF11A rs8083511 1 A/C AA 5
92._14q32.33 rs2003168 1 C/T AA 5
93._1q41 rs4285687 1 A/G AG 5
94._7p15.3 rs4722094 1 C/T TT 5
95._5q35.2 rs923520 1 G/A CT 5
96._10q26.13 CTBP2 rs10901850 1 C/T CC 5
97._1p21.1 rs12035891 1 A/C AA 5
98._9p21.3 rs829751 1 A/G AG 5
99._15q21.1 rs4775671 1 A/C AA 5
100._9q33.1 DBC1 rs10435884 1 C/T CC 5
101._6p21.1 GUCA1A rs7762152 1 A/G GG 5
102._17q22 rs4968363 1 C/T TT 5
103._18q21.1 rs8091406 1 A/G AA 5
104._13q21.1 rs795659 1 C/T TT 5
105._13q21.33 rs9529500 1 C/T CC 5
106._5p15.33 TPPP rs1709544 1 C/T TT 5
107._14q21.1 TTC6 rs17107115 1 A/G AA 5
108._8p23.1 DEFB1 rs2738173 1 C/T AA 5
109._17p11.2 rs8079482 1 A/G AG 5
110._8p21.3 PHYHIP rs4871976 1 A/G AG 5
111._5q32 rs4705423 1 G/T TT 5
112._8q24.3 PARP10 rs11785060 1 C/T CC 5
113._7p14.1 rs4520070 1 G/T TT 5
114._6q21 ARMC2 rs911475 1 G/A CC 5
115._7p14.1 POU6F2 rs9986786 1 C/T CC 5
116._12q24.33 rs11615979 1 C/T CT 5
117._9p21.3 CDKN2B rs1063192 1 T/C AA 5
118._16p13.12 rs231130 1 C/T CT 5
119._16p12.1 rs12446827 1 A/G AG 5
120._4q12 rs1353005 1 G/T GT 5
121._4q31.3 rs361147 1 A/C TT 5
122._2p15 rs6713620 1 C/T CT 5
123._4q26 ANK2 rs9307389 1 A/C CC 5
124._6p21.32 BTNL2 rs3763305 1 A/G GG 5
125._2p21 rs924114 1 A/G TT 5
126._6q15 BACH2 rs176765 1 T/G AC 5
127._21q22.13 CHAF1B rs2835342 1 G/T TT 5
128._6q25.3 LOC202459 rs3127162 1 C/T AG 5
129._8q22.1 MATN2 rs11996075 1 C/T CC 5
130._16p13.3 LUC7L rs1203981 1 C/T CT 5
131._9p21.3 rs2157719 1 A/G TT 5
132._1q44 SMYD3 rs2788015 1 C/T CC 5
133._8p12 FGFR1 rs7825208 1 A/G AA 5
134._5q33.1 SLC6A7 rs17111051 1 A/C CC 5
135._16q24.2 rs2334207 1 G/T GG 5
136._4p16.1 SORCS2 rs6812745 1 A/G AG 5
137._3q23 CLSTN2 rs966866 1 G/A CT 5
138._2p24.3 rs1568282 1 A/G CC 5
139._6p24.3 rs2764085 1 C/T CT 5
140._1q23.3 ATF6 rs12086247 1 A/G AG 5
141._13q31.1 rs12585627 1 A/G AA 5
142._1q44 rs871840 1 G/A CT 5
143._13q31.3 GPC6 rs17702471 1 A/G AA 5
144._5q11.2 rs254487 1 G/T TT 5
145._3p24.3 rs4373084 1 G/T GG 5
146._19p13.3 C19orf36 rs25673 1 G/A CT 5
147._8q22.1 rs278600 1 A/C GG 5
148._14q32.12 CHGA rs1316506 1 A/G GG 5
149._17p13.1 NTN1 rs3785977 1 A/G AG 5
150._3p24.3 rs6807885 1 C/T CC 5

Research references cited by consumer genomic companies:

  1. Sebastiani P et al; Genetic Signatures of Exceptional Longevity in Humans; Science; 2010 Nov 11; epub.

Glossary:
Locus (plural loci): the specific location of a gene or DNA sequence on a chromosome, (e.g.; 8p21.1 is the p21.1 region on Chromosome 8).
Gene: a series of variants at a locus that code for proteins or RNA chains.
Variant: the specific location with two alleles (e.g.; 'CG') or genotype values. Companies may review different variants in the same gene and locus.

Software licensing: BSD (DIYgenomics GitHub)


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