DIYgenomics ... understand your genome
Side-by-side comparison of locus, gene and variant information for 200 drugs (clopidogrel (Plavix), morphine, sildenafil (Viagra), warfarin, etc.). If a variant is reviewed, the underlying research references cited are posted in the table below. 'Sample data' is information from one person's 23andme file; not all the variants reviewed for drugs are genotyped currently by 23andme. One or two variant mutations could be interpreted as the usual dose of the drug possibly being 'less efficacious.' Green is the normal genotype, red is the mutation. * means that the FDA has validated genomic biomarkers for this drug. 'Rank' is a composite score assigned to the variant by DIYgenomics per journal ranking, number of cases and controls, p-value, and odds ratio (rank assessment methodology).
NOTE: The information on this page is intended for research and educational purposes only, and is not for diagnostic use.
|Locus||Gene||Variant||PharmGKB||Navigenics||23andMe||Pathway Genomics||dbSNP (Nrml/Rsk)||Sample data||Rank|
|chr6:31654768||LTB; LST1; TNF||rs3093726||1,3,6,7,8||C/T||TT||4|
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